During the holiday season, it’s typical for people to indulge in food, but this year may present a new experience for many Americans using weight loss medications. Those utilizing GLP-1 agonists, such as Ozempic or Wegovy, are likely to find Thanksgiving different, as the mechanism of these drugs reduces stomach emptying. Dr. Jon LaPook, CBS News’ chief medical correspondent, warned that overeating could lead to unpleasant effects such as nausea, vomiting, and heartburn due to increased stomach acid.

It’s vital to be aware of how long it takes to feel full. According to LaPook, it takes about 20 minutes from eating for your brain to register that you have consumed food. Fast consumption of a large Thanksgiving meal, especially after a long fasting period, can lead to feeling overwhelmed and unwell. Instead of feeling satisfied, one might experience discomfort and the need to lie down.

LaPook also suggests limiting alcohol intake until later in the meal, as combining alcohol with fatty foods can further delay stomach emptying. Eating earlier in the day is another practical tip he provides, allowing more time for the stomach to clear and helping mitigate post-meal discomfort. Adopting these strategies can help individuals enjoy the holiday without overindulging.